Science Behind the Therapy
Wound Healing Begins at the Cellular Level
Understanding the Science of V.A.C. Therapy
With more than 918 peer-reviewed articles, the clinical and economic benefits of V.A.C.® (Vacuum Assisted Closure®) Therapy, also known as NPWT (Negative Pressure Wound Therapy) are widely known: faster20 and more effective5 than gauze11,14, leading to improved patient's Quality of Life1 and cost - effectiveness3. However, it is equally important to understand how NPWT, namely V.A.C. Therapy works deep inside the wound to achieve the superior clinical outcomes. The following sections describe how V.A.C. Therapy promotes cellular wound healing and how its unique mechanisms of action differentiate it from other Negative Pressure Wound Therapy (NPWT) devices.
- What Makes Up the V.A.C. Therapy System
- How V.A.C. Therapy Works on the Cellular Level
- How V.A.C. Therapy Removes Barriers to Healing
Three Critical Components, One Unique Integrated System
The V.A.C. Therapy System is comprised of three essential components that actively work together to help induce celluwound healing through promotion of granulation tissue formation2,12,13.
- V.A.C. Therapy Unit Provides intermittent and continuous therapy with integrated patient safety features.
- SensaT.R.A.C. Technology Regulates pressure at the wound site to provide accurate delivery of prescribed therapy settings
- V.A.C. GranuFoam Dressings Help induce the necessary mechanisms to promote granulation tissue formation
The Science Behind V.A.C. Therapy: Macrostrain and Microstrain
Under negative pressure, V.A.C. Therapy with proprietary V.A.C. GranuFoam™ Dressings applies both mechanical and biological forces to the wound to create an environment that promotes wound healing. These forces are known as macrostrain and microstrain.
Macrostrain is the visible stretch that occurs when negative pressure contracts the foam.
- Draws wound edges together
- Provides direct and complete wound bed contact
- Evenly distributes negative pressure
- Removes exudate and infectious materials
Microstrain is the microdeformation at the cellular level, which leads to cell stretch.
- Reduces edema
- Promotes perfusion
- Increases cellular proliferation and migration
- Promotes granulation tissue formation
Revised illustration that shows the “circles” that depict the mechanisms of macrostrain and microstrain
Watch a video of how V.A.C. Therapy works on the cellular level through macrostrain and microstrain.
V.A.C. Therapy Mechanisms of Action
V.A.C. Therapy provides a closed, moist environment that promotes wound healing through the following mechanisms:
|Wound Healing Barrier||V.A.C. Therapy Mechanism|
|Excessive bacterial burden||Removes infectious materials|
|Inadequate protection against infection||Provides protected wound healing environment|
|Excess exudate||Removes exudate|
|Excess edema (interstitial fluid)||Reduces edema (interstitial fluid)|
|Absence of moisture||Provides a moist wound healing environment|
|Lack of adequate blood flow||Promotes perfusion|
|Lack of cellular activity||Promotes cellular migration and proliferation during granulation tissue formation|
V.A.C. Therapy uses SensaT.R.A.C.™ (Therapeutic Regulated Accurate Care) to:
- Monitor and maintain target pressure at the wound site for consistent therapy delivery
- Reduce tubing blocks and false alarms through enhanced fluid dynamics
- Enable Smart Alarms™ for enhanced patient safety
- Provide easier and efficient V.A.C. Dressing applications
- Enhance patient comfort